{{ua_lang=='cn'?"分子互作检测":"SPR Service"}}

{{ua_lang=='cn'?"采用SPR技术，精准检测多种靶点蛋白、细胞因子及抗体药物分子互作特点。":"Using SPR technology to accurately detect the interaction characteristics of multiple target proteins, cytokines, and antibody drug molecules."}}

{{ua_lang=='cn'?"表面等离子共振技术(Surface Plasmon Resonance,简称SPR)是一种以光学为基础的分析技术。SPR技术利用光发生全反射时消逝波与金属表面等离子波形成共振，导致反射光大幅度减弱。当入射光波长固定时，反射光的强度是入射角的函数，其中反射光强度最低时对应的入射角为共振角(Resonance Angle)。金属表面的介质的折射率非常敏感，当表面介质的属性改变或附着量改变时，共振角将不同。":"Surface plasmon resonance (SPR) is an optical based analysis technology. SPR technology utilizes the resonance between evanescent waves and metal surface plasma waves during total reflection of light, resulting in a significant reduction in reflected light. When the wavelength of the incident light is fixed, the intensity of the reflected light is a function of the incident angle, and the incident angle corresponding to the lowest intensity of the reflected light is the resonance angle. The refractive index of the medium on the metal surface is very sensitive, and when the properties or adhesion of the surface medium change, the resonance angle will be different."}}

{{ua_lang=='cn'?"简单来说SPR是根据金属表面结合的配体的量或是否结合配体产生不同的共振角，共振角的改变与Ligand-Analyte的数量成正比，以此确定配体与Analyte结合的状态和Ka(热力学亲和常数)。":"Simply put, SPR is based on the amount of ligands bound to the metal surface or whether they bind to generate different resonance angles. The change in resonance angle is proportional to the number of Ligand Analytes, in order to determine the binding state and Ka (thermodynamic affinity constant) of ligands with Analytes."}}

{{ua_lang=='cn'?"平台概况":"Platform Introduction"}}

{{ua_lang=='cn'?"优爱SPR技术平台采用Biacore T200，目前已经完成多个靶点及细胞因子的亲和力和活性的检测。检测分子类别包括但不限于FcR受体、热门靶点蛋白(PD-1/PD-L1、CD47、EFGR)、细胞因子，多种抗体(单抗、双抗、ADC抗体)等。":"UA SPR technology platform adopts Biacore T200 and has completed the detection of the affinity and activity of multiple targets and cytokines. The detection molecular categories include but are not limited to FcR receptors, popular target proteins (PD-1/PD-L1, CD47, EFGR), cytokines, and various antibodies (monoclonal antibodies, dual antibodies, ADC antibodies)."}}

  • {{ua_lang=='cn'?"多类蛋白检测经验成功率高":"Multiply Protein Experience"}}

  • {{ua_lang=='cn'?"多种现货蛋白加快检测周期":"Hundred Proteins Accelerate TAT"}}

  • {{ua_lang=='cn'?"性价比超高":"Cost-effective"}}

{{ua_lang=='cn'?"案例":"Case"}}

{{ua_lang=='cn'?"靶点蛋白亲和力检测":"Target Protein Affinity"}}

EGFR Fc Chimera, Human (Cat. No. UA010174) captured on Protein A Biosenor, can bind HB-EGF, Human (Cat. No. UA040029) with an affinity constant of 0.39μM as determined in SPR assay.

{{ua_lang=='cn'?"受体蛋白亲和力检测":"Receptor Protein"}}

Anti-His antibody Immobilized on CM5 Chip captured CD16 His Tag, Cynomolgus (Cat. No. UA020018), can bind IgG1-Fc (UA050001) with an affinity constant of 0.311μM as determined in SPR assay (Biacore T200).

{{ua_lang=='cn'?"抗体和靶点蛋白":"Antibody and Target Protein"}}

Anti-Human HER2(Trastuzumab) Monoclonal Antibody captured on Protein A Biosenor, can bind Her2 His Tag, Human (Cat. No. UA010176) with an affinity constant of 1.35 nM as determined in SPR assay.

{{ua_lang=='cn'?"您可以直接下载服务需求表，填写完成后发送至order@ua-bio.com，我们将尽快联系您。":"You can directly download the service demand form, fill it out, and send it to order@ua-bio.com We will contact you as soon as possible"}}