MOG(1-125) Protein, Human

Myelin Oligodendrocyte Glycoprotein (MOG) is a member of the immunoglobulin superfamily and is expressed exclusively in central nervous system (CNS). Although MOG protein constitutes only 0.01-0.05% of the CNS myelin proteins, it was demonstrated that MOG protein is a crucial autoantigen for multiple sclerosis in humans and experimental autoimmune encephalomyelitis (EAE) in rodents and monkeys . The purified human rMOG is recommended for in vitro studies such as T cell and B cell responses, cytokine response, antigen presentation, Western blotting, and ELISA as well as for in vivo study such as EAE induction in mice and monkeys. The following dosages are recommended: 5-20 μg/ml for in vitro study and 50-100 μg per animal for in vivo study