Technical Articles

The core of MHC tetramers lies in their unique molecular architecture. MHC molecules, responsible for presenting antigenic peptides to T cells in the immune system, are engineered into tetrameric structures through the biotin-streptavidin system. This design significantly enhances the binding affinity and stability of MHC-peptide complexes with T cell receptors (TCRs), addressing the limitations of traditional MHC-peptide monomers with low affinity and rapid dissociation rates.