Technical Articles

This article focuses on the molecular characteristics and biological functions of activin receptor type IIB (ActRIIB), systematically elaborating its high expression features in skeletal muscle, cardiac muscle, and adipose tissue as a TGF-β superfamily receptor, as well as its high sensitivity to myostatin and activin B. It analyzes its therapeutic potential in muscle atrophy diseases, cancer cachexia, and metabolic disorders, along with the advantages and challenges in the development of targeted drugs.

This article systematically elaborates on the molecular characteristics and biological functions of activin receptor type IIB (ActRIIB), focusing on its expression features in skeletal muscle, cardiac muscle, and adipose tissue as a TGF-β superfamily receptor, as well as its high sensitivity to myostatin and activin B. It analyzes its therapeutic potential in muscle atrophy diseases, cancer cachexia, and metabolic disorders, along with the advantages and challenges of targeted drug development.