Technical Articles

This article is based on the fundamental architecture of the immune system and the physiological functions of B cells, systematically elaborating on the structural characteristics of CD19 as a lineage-specific molecule in B cells, its co-receptor mechanism in B cell receptor signaling transduction, its expression patterns in B cell malignancies, and the clinical translation progress of chimeric antigen receptor T cell (CAR-T) therapies targeting this molecule. Furthermore, it introduces the detection and application value of fluorescently labeled recombinant proteins.