Technical Articles

This article systematically elaborates on the molecular structural characteristics of guanylate cyclase C (GUCY2C) as an intestine-specific transmembrane receptor, its dual role as a tumor suppressor and biomarker in the development and progression of colorectal cancer, its specific overexpression pattern in metastatic colorectal cancer, and its clinical translational progress as a target for immunotherapies such as CAR-T. Additionally, it introduces the application value of fluorescently labeled recombinant proteins in detection.