Technical Articles

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by progressive cognitive impairment, with pathogenesis involving multiple pathological processes such as amyloid-β (Aβ) deposition, abnormal phosphorylation of Tau protein, oxidative stress, and neuroinflammation.

The discovery of IL-3 derived from astrocytes as a regulatory factor of microglial function provides a new perspective for the pathogenesis and treatment of Alzheimer's disease. By reprogramming microglia to enhance A β clearance ability, IL-3 represents a powerful endogenous mechanism that can be used for therapeutic purposes to prevent or slow down disease progression.

Tau protein is a microtubule-associated protein predominantly found in neurons, playing a crucial role in maintaining cellular cytoskeletal stability and neuronal function. However, when Tau protein undergoes abnormal modifications (such as hyperphosphorylation), it forms neurofibrillary tangles (NFTs), which are the hallmark pathological features of Alzheimer's disease (AD) and other tauopathies.