Technical Articles

B cell activation

重组人cd40 fc蛋白：做 B 细胞与 DC 激活实验，Fc 段带来的干扰怎么处理？

Working with CD40 Fc Chimera: Avoiding Fc-Mediated Interference in B Cell and DC Activation Assays

2026-10-16

A practical guide to recombinant CD40/TNFRSF5 Fc chimera: choosing Fc controls, plate-coating versus soluble formats, crosslinking strategy and how to separate CD40-specific signaling from Fc-mediated background.

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Immunity/Inflamma
CD40 Fc chimera
Fc interference
crosslinking
B cell activation
dendritic cell
co-culture
UA010194

The dual-signal mechanism and regulatory strategies of B cell activation

2026-08-18

This article systematically elaborates on the synergistic role of the first signal mediated by the BCR and the second signal provided by costimulatory molecules in B cell activation, analyzing the differences between T cell-dependent and independent activation pathways and their biological significance.

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Cell Biology
B cell activation

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