Technical Articles

CD22 is a member of the sialic acid-binding immunoglobulin-type lectin family, a type I transmembrane protein that specifically binds to sialic acid-containing glycans and inhibits B-cell receptor signaling through its immunoreceptor tyrosine-based inhibitory motif, thereby maintaining humoral immune homeostasis.

CD22, also known as Siglec-2, is a key member of the sialic acid-binding immunoglobulin-like lectin family, belonging to type I transmembrane proteins with a molecular weight of 140 kDa.

The immune system in the human body has functions such as immune surveillance, immune defense, and immune homeostasis. Its ability to resist the invasion of foreign pathogens and eliminate malignant mutations and senescent cells is primarily achieved through the innate immune system, composed of macrophages and basophils, as well as the adaptive immune system, consisting of T lymphocytes and B lymphocytes.

B cells are a core component of the adaptive immune system, mediating humoral immune responses by differentiating into plasma cells to produce antibodies. Recent studies have revealed significant functional heterogeneity among B cells, with different subsets playing pro-inflammatory or anti-inflammatory roles in immune regulation, and their functional states are precisely modulated by cytokine networks in the microenvironment.

PE-Labeled CD19 His Tag is a core B-lymphocyte-specific detection probe, specifically designed for the precise identification, quantification, and analysis of all mature B cells and their precursors.

B cell polarization refers to the process by which naïve B cells, driven by antigens and specific signals (particularly cytokines), differentiate into distinct functional effector subsets. This is not merely a simple activation and proliferation, but rather a functional differentiation that determines antibody class, immunological memory, and tissue localization.

This article describes the mechanism of action of Siglec-2/CD22, expounds the expression roles of Siglec-2/CD22 in the development, activation, and functional regulation of B cells, and illustrates their importance.

B cells play a vital role in the human immune system. They are the main force of humoral immunity and resist the invasion of foreign pathogens by secreting antibodies.

In the field of immunotherapy, CD19 has become a highly anticipated "star target". Scientists, clinicians and patients have high hopes for it. So, why is CD19 so important? What role does it play in immunotherapy? Today, let us step into the world of CD19 and unveil its mystery.