Technical Articles

Targeted protein degradation technologies have made significant progress in the fields of chemical biology and drug discovery in recent years. Among them, PROTAC technology achieves specific ubiquitination and proteasomal degradation of target proteins by inducing proximity between the target protein and E3 ubiquitin ligase.

In the field of targeted protein degradation, particularly in the development of molecular glue drugs targeting the critical transcription factor BCL6, rapidly and accurately quantifying the efficiency of ternary complex formation induced by candidate compounds is a key step to accelerate lead compound discovery and optimization.