Technical Articles

BRD4/CRBN PROTAC Kit

The role and mechanism of BRD4 signaling pathway in stress-induced osteoarthritis and targeted degradation therapy strategies

2026-01-21

Temporomandibular joint osteoarthritis is a chronic disease characterized by degenerative changes in articular cartilage, subchondral bone resorption, and extracellular matrix damage, with excessive mechanical stress considered a key pathogenic factor in its development and progression.

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Immunity/Inflamma
BRD4/CRBN PROTAC Kit
Osteoarthritis
Temporomandibular joint osteoarthritis

Epigenetic regulator BRD4: from basic functions to targeted degradation strategies

2026-01-08

BRD4 (Bromodomain-containing protein 4) is a key member of the BET protein family, functioning as a critical transcriptional regulator involved in multi-level gene expression regulation.

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Cancer
BRD4/CRBN PROTAC Kit
Epigenetic regulator
Transcriptional regulator

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