Technical Articles

This article focuses on the molecular characteristics and biological functions of the CD3ε protein, systematically elaborating its domain composition and gene localization as a core component of the TCR-CD3 complex, analyzing the key role of CD3ε in the initiation of ITAM phosphorylation signaling and the recruitment of downstream signaling proteins, and exploring the clinical significance of CD3ε in T-cell tumor diagnosis, autoimmune diseases, and celiac disease.