Technical Articles

CRBN/DDB1 Complex Protein

Structural Basis and Drug Development Potential of the CRBN-DDB1 Complex: The Substrate Recognition Module of E3 Ubiquitin Ligase

2026-07-29

This article systematically elucidates the molecular basis of CRBN and DDB1 forming a functional complex, analyzes its core role as the substrate recognition module of the CUL4-RING E3 ubiquitin ligase complex, and explores the pivotal position of this complex in the development of PROTACs and molecular glue drugs.

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Signaling Pathway
CRBN/DDB1 Complex Protein

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