Technical Articles

Cancer Cachexia

ActRIIB Protein: The "Core Brake" of Muscle Growth and a Revolutionary Target for Next-Generation Therapeutics

2025-12-02

The activin receptor type IIB (ActRIIB) is a pivotal signaling hub in the transforming growth factor-β (TGF-β) superfamily. Far from being a simple receptor, it serves as a "master switch" regulating muscle growth, erythropoiesis, and systemic metabolic homeostasis.

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Signaling Pathway
ActRIIB
TGF-β
Activin Receptor Type-2B
Muscle Atrophy
Cancer Cachexia

ActRIIB Protein: The "Core Brake" of Muscle Growth and a Novel Therapeutic Target for Diseases

2025-11-28

ActRIIB (Activin Receptor Type IIB) is a key signaling receptor in the TGF-β superfamily, serving as the "core negative regulator" of muscle growth and playing a decisive role in muscle atrophy diseases, anemia, and metabolic disorders.

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Cancer
ActRIIB
TGF-β
Activin Receptor Type-2B
Muscle Atrophy
Cancer Cachexia

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