Technical Articles

This article focuses on the central role of the Caspase family of proteases in apoptotic signal transduction, systematically elucidating the cascade reaction mechanisms through which they are activated via the intrinsic and extrinsic pathways. It analyzes the hierarchical functional分工 between initiator Caspases and effector Caspases, as well as the cleavage effects on key downstream substrates.

This article systematically elucidates the dual role of Caspase-3/7 in intestinal diseases, highlighting its anti-inflammatory and protective effects by inhibiting pyroptosis and ensuring stem cell regeneration to maintain intestinal epithelial barrier homeostasis, while also exploring its contribution to inflammation-driven tumor initiation.

This article systematically elucidates the central role of Caspase-3/7 in intestinal homeostasis and disease, highlighting its anti-inflammatory barrier function by inhibiting GSDMD-mediated pyroptosis and ensuring the regenerative capacity of intestinal stem cells, while also exploring its "double-edged sword" effect in inflammation-driven tumor initiation.