Technical Articles

Myelin oligodendrocyte glycoprotein is a myelin protein specifically expressed on the surface of oligodendrocytes in the central nervous system, located in the outermost layer of the myelin sheath. It consists of 218 amino acids and belongs to the immunoglobulin superfamily.

In the human central nervous system, myelin oligodendrocyte glycoprotein (MOG) is a key protein that plays an important role in maintaining the integrity and function of nerve myelin.

Myelin oligodendrocyte glycoprotein (MOG) is an essential component of the outermost layer of myelin sheath in the central nervous system (CNS). Its molecular structure consists of 218 amino acids with a molecular weight of approximately 18-22 kDa, belonging to the immunoglobulin superfamily. MOG expression is highly specific, restricted to oligodendrocytes and the outermost myelin layer, constituting 0.01%-0.05% of total myelin proteins. This spatial distribution renders it a potential target for immune system attacks.