Technical Articles

Degenerative Joint Disease

Alexa Fluor 488标记的EGF蛋白在软骨EGFR信号通路研究中的应用

Application of Alexa Fluor 488-labeled EGF protein in the study of EGFR signaling pathway in cartilage

2026-04-23

Osteoarthritis is a common degenerative joint disease characterized by pathological features such as joint cartilage degeneration, subchondral bone sclerosis, and synovial inflammation.

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Signaling Pathway
EGF Protein
Osteoarthritis
Degenerative Joint Disease

基于TR-FRET技术的BRD4靶向PROTAC降解剂在颞下颌关节骨关节炎中的研究

Study of BRD4-targeting PROTAC degraders based on TR-FRET technology in temporomandibular joint osteoarthritis

2026-04-15

The essence of temporomandibular joint osteoarthritis is a degenerative joint disorder, with excessive mechanical stress being a significant cause of the disease. Thinning of cartilage, subchondral bone resorption, and extracellular matrix damage are the primary pathological changes induced by excessive mechanical stress.

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Immunity/Inflamma
Degenerative Joint Disease
Temporomandibular Joint Osteoarthritis
BRD4

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