Technical Articles

FMS-like tyrosine kinase 3 ligand (Flt-3L) is a crucial hematopoietic cytokine, belonging to type I transmembrane proteins, and its soluble form is generated through proteolytic cleavage.

Aging represents a complex biological process characterized by the progressive decline of multiple physiological functions. The Klotho protein has emerged as a crucial regulator in this process, exerting anti-aging effects through modulation of various signaling pathways including Wnt, insulin signaling, and phosphate metabolism. This review summarizes current understanding of Klotho's molecular mechanisms and its therapeutic applications for age-related diseases.