Technical Articles

Multiple Sclerosis (MS) is a classic autoimmune disease whose pathological mechanisms are not yet fully understood. To further investigate and comprehend the pathogenesis of MS, researchers widely employ the Experimental Autoimmune Encephalomyelitis (EAE) animal model. In these models, Myelin Oligodendrocyte Glycoprotein (MOG) is utilized as an immunogen to induce autoimmune lesions, mimicking the progression of MS. This article reviews the establishment and characteristics of the MOG-induced EAE animal model, its applications in studying autoimmune diseases, and explores the potential role of this model in elucidating the pathophysiology of MS.