Technical Articles

This article focuses on the molecular characteristics and biological functions of epidermal growth factor (EGF), systematically elaborating its core mechanism of activating EGFR to initiate intracellular signaling cascades and promote epidermal cell proliferation and migration. It also analyzes the significant therapeutic effects of EGF in wound healing and its limitations in non-invasive skincare.

Growth factors are a class of polypeptides that regulate cell growth and various other biological functions by binding to specific, high-affinity receptors on the cell membrane. In academic literature, they are often referred to as "growth peptides." These molecules are widely distributed in various tissues of the body, including developing embryonic tissues and differentiated mature tissues.

Gastric organoids, in simple terms, are three-dimensional (3D) miniaturized organs derived from stem cells in laboratory culture dishes. The construction of normal mouse gastric organoids typically begins with the isolation of adult stem cells or embryonic stem cells from mouse gastric tissue. These cells are cultured within a Matrigel matrix containing specific growth factors (such as EGF, Wnt, Noggin, etc.), which precisely simulate the stem cell niche microenvironment of the gastric mucosa in vivo.

In modern animal husbandry, the intestinal health of animals is the key to successful breeding. The intestine is not only the main place for nutrient digestion and absorption, but also bears the heavy responsibility of mucosal immunity, barrier function and microecological balance.