Technical Articles

Regulated Induced Proximity Targeting Chimeras (RIPTAC) is a novel heterobifunctional small-molecule therapeutic strategy that selectively induces death in tumor cells expressing the Target Protein (TP) by simultaneously binding to the tumor-specific TP and an essential cell survival Effector Protein (EP), forming a stable ternary complex. This mechanism is independent of the ubiquitin-proteasome pathway, overcoming the reliance on E3 ligases in Targeted Protein Degradation (TPD), and does not require the target protein itself to possess pathogenic functionality, thereby providing a new technological approach to expand the druggable target space.