Technical Articles

Epidermal growth factor is an important endogenous active substance in the human body and a classic member of the growth factor family. This protein consists of 53 amino acid residues, contains three disulfide bonds, and has a molecular weight of approximately 6 kilodaltons.

Epidermal growth factor is an important active substance in the human body and belongs to the earliest discovered members of the growth factor family. The human epidermal growth factor protein consists of 53 amino acid residues, contains three disulfide bonds, and has a molecular weight of approximately 6 kilodaltons.

Epidermal Growth Factor (EGF) represents a landmark discovery in the field of cell biology. The signaling pathway formed by EGF and its receptor (EGFR) serves as a core network regulating cell growth, proliferation, and differentiation. This article will delve into the molecular mechanisms of the EGF/EGFR signaling pathway from a technical perspective, with a focused analysis of its critical roles in cancer, impaired tissue repair, and inflammatory diseases, concluding with an outlook on therapeutic strategies targeting this pathway.