Technical Articles

Based on the fundamental principles of chimeric antigen receptor T-cell (CAR-T) therapy, this article systematically elaborates on the challenges of antigen escape faced by single-target CAR-T in B-cell malignancies. It analyzes the complementary expression patterns and clinical evidence of CD19 and CD22 as targeting antigens for B-cell lineage tumors, and explores the theoretical basis and clinical translation prospects of the CD19/CD22 dual-targeting strategy in overcoming drug resistance and prolonging disease control duration.