Technical Articles

This article systematically elaborates on the molecular structural characteristics of CD7 as a member of the immunoglobulin superfamily and its expression patterns in T-cell and NK-cell lineages. It analyzes the coreceptor mechanisms by which CD7 mediates T-cell activation and NK-cell functional regulation, and explores the high-expression features of CD7 in hematologic malignancies such as T-cell acute lymphoblastic leukemia, acute myeloid leukemia, and NK/T-cell lymphoma, as well as its clinical translational value as a target for CAR-T therapy.