Technical Articles

Based on the findings of a systematic comparative study, this article elucidates the experimental evidence demonstrating the superiority of CD7 over other receptors in T cell-targeted lipid nanoparticle (tLNP)-mRNA delivery. It analyzes the differential impact of receptor abundance and internalization kinetics on delivery efficiency, reveals the mechanistic basis underlying CD7's high efficiency in mediating mRNA delivery, and highlights its application value in the in vivo engineering of CAR-T cells. Additionally, it introduces the detection applications of fluorescently labeled recombinant proteins in related research.