Technical Articles

This article systematically elucidates the physiological functions and pathological mutations of the epidermal growth factor receptor (EGFR) gene, focusing on its short-term controllable mechanisms in normal cellular signal regulation and its signal dysregulation caused by mutations in lung cancer. It analyzes the epidemiological characteristics of EGFR mutations in Chinese lung cancer patients and the structural basis of different mutation subtypes, while exploring their clinical value as biomarkers for targeted therapy.