Technical Articles

This article systematically elucidates the molecular characteristics and biological functions of FMS-like tyrosine kinase 3 ligand (FLT-3L), focusing on its structural features as a type I transmembrane protein and the mechanism by which it drives the proliferation and differentiation of hematopoietic stem cells through activation of the FLT3 receptor. It also analyzes its core regulatory role in dendritic cell development, as well as the generation of NK cells and B cells.

This article systematically elaborates on the molecular characteristics and biological functions of the FLT3 receptor and its ligand FLT3L, focusing on the regulatory role of FLT3 as a type III tyrosine kinase receptor in hematopoietic progenitor cell development. It also analyzes the pathological mechanisms by which FLT3 mutations drive abnormal proliferation in acute myeloid leukemia (AML).

Acute myeloid leukemia is a highly heterogeneous group of hematologic malignancies, and its prognosis assessment involves multiple factors. Traditionally, age, history of hematologic disorders, karyotype, and gene mutation profiles have been important bases for evaluating patient prognosis, and these factors collectively determine the selection of treatment strategies.