Technical Articles

Granulocyte colony-stimulating factor (G-CSF) is a core cytokine that regulates granulocyte hematopoiesis and plays an irreplaceable role in the generation and maturation of neutrophils. It specifically binds to the granulocyte colony-stimulating factor receptor (G-CSFR), activates the JAK-STAT signaling pathway, promotes the directional differentiation of hematopoietic stem cells in the bone marrow into neutrophils, and accelerates the release of mature neutrophils. This mechanism not only plays a core role in the regulation of basic hematopoiesis, but also shows significant efficacy in the treatment of myelosuppressive neutropenia (FN) caused by radiotherapy and chemotherapy.