Technical Articles

This article will provide an in-depth analysis of Alexa Fluor 647-Labeled GPC3 His Tag protein—an advanced bioconjugate. We will elaborate on its composition, working principles, and focus on its profound association with major diseases such as hepatocellular carcinoma (HCC), demonstrating its pivotal role in precision cancer diagnosis, drug development, and immunotherapy.

GPC3 (Glypican-3) is a glycoprotein located on the surface of cell membranes, belonging to the heparan sulfate proteoglycan family. Its gene is located in the q26.1 region of the human X chromosome, encoding a protein consisting of 580 amino acids with a molecular weight of approximately 70 kDa.