Technical Articles

GTP hydrolysis

Conformational regulation of the KRAS molecular switch—Structural basis for targeting "undruggable" targets

2026-06-10

KRAS is the most frequently mutated subtype in the RAS family, and its dysfunction drives approximately one-quarter of human cancers. The KRAS protein belongs to the small GTPase family, cycling between the active GTP-bound state and the inactive GDP-bound state, functioning as a molecular switch.

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Cancer
KRAS structure
conformational dynamics
Switch I/Switch II
GTP hydrolysis
effector binding
small-molecule binding pockets

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