Technical Articles

Guanylyl cyclase C is a transmembrane protein belonging to the receptor guanylyl cyclase family. It is activated by Escherichia coli heat-stable enterotoxin, guanylin, and uroguanylin, transmitting extracellular signals to the intracellular environment and participating in the regulation of intestinal function.

Guanylyl cyclase C, also known as GUC2C or STAR, is a guanylyl cyclase that catalyzes the synthesis of cyclic GMP from GTP. It plays a key role in regulating intestinal homeostasis and is central to intestinal health and colorectal cancer development, making it a highly promising therapeutic target.

Guanylyl cyclase C belongs to the receptor guanylyl cyclase family and is the intestinal receptor for bacterial heat-stable enterotoxins, hence it is also known as the heat-stable enterotoxin receptor. The human GUCY2C gene is located on chromosome 12q12, and its encoded product is a type I transmembrane protein with a molecular weight of approximately 120 kDa.

鸟苷酸环化酶C是一种在人体中由GUCY2C基因编码的酶，属于受体鸟苷酸环化酶家族。该酶是细菌热稳定肠毒素的肠道受体，因此又称为热稳定肠毒素受体。