Technical Articles

Osteogenesis Imperfecta (OI), also known as brittle bone disease, is a rare genetic connective tissue disorder with an incidence of approximately 1/10,000 to 1/20,000. Patients often present with low bone mass, increased bone fragility, recurrent fractures, and may exhibit extra-skeletal manifestations such as blue sclerae, hearing loss, and dentinogenesis imperfecta.