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IL-21: The Immune System's "Versatile Coordinator" and the Double-Edged Sword in Disease Treatment

2025-12-03

Interleukin-21 (IL-21) is a pleiotropic cytokine produced by activated T cells, serving as a central messenger in coordinating humoral immunity, cellular immunity, and immune tolerance. It plays a complex and critical role in promoting antibody production, cytotoxic cell activation, and immune regulation.

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Cancer
IL-21
Interleukin-21
Follicular Helper T Cells (Tfh)
Germinal Center
Autoimmune Diseases

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