Technical Articles

Antigen - specific T cells are central effector cells of the adaptive immune system. They play a key role in viral infection, tumor immunosurveillance, and vaccine - induced protective immunity. Traditional detection methods, limited by low sensitivity or complex procedures, struggle to precisely quantify low - frequency antigen - specific T cells. The H-2Db MHC tetramer technology has broken through this barrier. By forming high - affinity polymeric complexes, it enables single - cell detection and functional analysis of CD8+ T cells.