Technical Articles

In the immune system's intricate network, abnormal activation of signaling pathways is central to various inflammatory diseases and tumorigenesis. IL-1 receptor-associated kinase 4 (IRAK4), a key node in the TLR/IL-1R signaling pathway, has dual functions (kinase activity and scaffolding function), making it a core target for regulating innate and adaptive immunity. Recent advances in IRAK4-targeted drug development offer new strategies for treating autoimmune diseases and cancers.