Technical Articles

This article focuses on the central role of TANK-binding kinase 1 (TBK1) in the type I interferon signaling pathway, systematically elucidates the negative regulatory mechanism of the autophagy-related protein ATG4B on TBK1, analyzes the molecular basis of ATG4B-mediated selective autophagic degradation of TBK1 through GABARAP and its pathological significance in viral infection, explores the potential therapeutic value of ATG4B inhibitors in enhancing antiviral immune responses, and introduces the detection applications of enzyme-labeled recombinant proteins in related research.