Technical Articles

This study, based on a mouse model of aortic constriction, systematically elucidates the critical role of myeloid cell-specific ErbB3 signaling in the early adaptation of non-ischemic cardiomyopathy. It focuses on analyzing the mechanism by which this signaling pathway mediates cardiac myeloid cell recruitment and promotes non-immune cell proliferation in male mice, while revealing the sex-specific characteristics of acute heart failure induced by ErbB3 signaling deficiency.