Technical Articles

Keratinocyte growth factor (KGF), also known as fibroblast growth factor 7 (FGF-7), is a key member of the fibroblast growth factor family. It is secreted by mesenchymal-derived cells and exerts paracrine regulatory effects by specifically binding to its epithelial cell receptor. This factor plays a critical role in promoting epithelial cell proliferation, tissue damage repair, and organ development, particularly demonstrating potential value in the regenerative treatment of endometrial damage. However, its inherent structural instability and rapid clearance in vivo hinder clinical translation. Advances in recombinant protein technology provide a feasible pathway to overcome this bottleneck.