Technical Articles

IL-18 is a member of the IL-1 family of cytokines, renowned for its potent ability to induce IFNγ production. However, both fundamental research and recent clinical observations suggest a more complex scenario. The unique biological characteristics of IL-18 at the levels of transcription, activation, secretion, neutralization, receptor distribution, and signaling contribute to explaining its pleiotropic roles in mucosal and systemic inflammation.