Technical Articles

Cytokine-induced killer (CIK) cells demonstrate broad application prospects in adoptive immunotherapy for tumors. As a highly efficient, non-MHC-restricted killer cell population, CIK cells can effectively recognize and eliminate various tumor cells with minimal side effects.

Interleukin-1 (IL-1) family is the core cytokine group regulating inflammatory response in the innate immune system. Its members participate in a variety of pathophysiological processes by binding specific receptor complexes. According to receptor binding characteristics, the IL-1 family can be divided into three subfamilies: IL-1, IL-18, and IL-36. Among them, the key co receptor IL-1R5 (i.e. IL-18R α) of the IL-18 subfamily plays an important role in infections, autoimmune diseases, and metabolic disorders.