Technical Articles

Interleukin-18 (IL-18) is a key member of the IL-1 cytokine superfamily, renowned for its potent pro-inflammatory properties and ability to induce interferon-γ production. As a "pioneer signal" in immune responses, it serves as both a weapon against infections and a "culprit" driving numerous chronic inflammatory and autoimmune diseases.

IL-18 is a key member of the IL-1 cytokine family and functions as a pro-inflammatory cytokine, playing a central role in both innate and acquired immunity.

IL-18 is a member of the IL-1 family of cytokines, renowned for its potent ability to induce IFNγ production. However, both fundamental research and recent clinical observations suggest a more complex scenario. The unique biological characteristics of IL-18 at the levels of transcription, activation, secretion, neutralization, receptor distribution, and signaling contribute to explaining its pleiotropic roles in mucosal and systemic inflammation.