Technical Articles

Interleukin-18 receptor alpha (IL-18RA, also known as IL-1R7) is a key component of the IL-18 signaling pathway and belongs to the IL-1 receptor family. IL-18 binds to IL-18RA and co receptor IL-18R β to form a complex, activating downstream NF - κ B and MAPK signaling pathways, thereby regulating innate and acquired immune responses.