Technical Articles

Interleukin-3 (IL-3), also known as Multi-CSF, is a key member of the hematopoietic growth factor family. Unlike IL-2, which primarily acts on mature lymphocytes, the core function of IL-3 lies in regulating the survival, proliferation, and differentiation of early hematopoietic stem/progenitor cells, exerting broad influence on the development of myeloid cells and the activity of various immune cells.

FLT-3L, fully known as FMS-like tyrosine kinase 3 ligand, is also referred to as FLT3 ligand or Flt3L. It is a critical cytokine produced by bone marrow stromal cells, among others. Its primary function is to regulate the proliferation, differentiation, and survival of hematopoietic stem cells by binding to the FLT3 receptor on the cell surface and activating downstream signaling pathways.