Technical Articles

Siglecs are a family of receptors that bind to sialic acid-containing glycans, belonging to the single-pass type I membrane proteins. Their extracellular region consists of 2 to 17 immunoglobulin (Ig) domains, with an N-terminal V-set Ig domain that binds sialic acid and a variable number of C2-set Ig domains.

CD24 is a widely expressed glycosylated protein on the surface of various cells, serving as an important immune regulator and stem cell marker that plays a key role in tumorigenesis, immune evasion, tissue repair, and infection response.

Immune checkpoints play a vital role in the human immune system. They are a class of proteins on immune cells that can regulate the activity of immune cells and maintain the balance of the immune system.