Technical Articles

Th17 cells are a subset of CD4+ T cells characterized by the secretion of IL-17A as their signature effector molecule, and their differentiation is regulated by the transcription factor RORγt. Th17 cells play a critical role in autoimmune diseases and inflammatory disorders, while also maintaining important functions in intestinal mucosal homeostasis.

Interleukin-18 receptor alpha (IL-18RA, also known as IL-1R7) is a key component of the IL-18 signaling pathway and belongs to the IL-1 receptor family. IL-18 binds to IL-18RA and co receptor IL-18R β to form a complex, activating downstream NF - κ B and MAPK signaling pathways, thereby regulating innate and acquired immune responses.

Autoimmune diseases, such as rheumatoid arthritis, psoriasis, and ankylosing spondylitis, are chronic inflammatory conditions caused by the immune system erroneously attacking the body's own tissues, significantly impairing patients' quality of life. In recent years, with the deepening understanding of the pathogenesis of these diseases, several key target proteins have been discovered and applied in treatment, bringing new hope to patients.