Technical Articles

The IL-17 family of cytokines plays a central driving role in the pathological processes of various autoimmune diseases. Among them, IL-17A and IL-17F, as key members of this family, share overlapping pro-inflammatory functions.

Systemic lupus erythematosus is a systemic autoimmune disease characterized by immune system dysregulation, which produces a large number of autoantibodies and attacks multiple organ systems, leading to widespread inflammation and tissue damage.

IL-17F is a crucial member of the interleukin-17 (IL-17) cytokine family, exhibiting high amino acid sequence homology (approximately 50%) with IL-17A.

IL-23 is a crucial heterodimeric cytokine composed of the p19 subunit and the p40 subunit of IL-12, and its specific receptor complex consists of the IL-12Rβ1 and IL-23Rα chains.

Autoimmune diseases are a group of pathological conditions caused by abnormal immune system function, characterized by the attack of normal tissues and organs by autoantibodies or autoreactive lymphocytes, leading to persistent inflammation and tissue damage.

Interleukin-2 (IL-2) is a four α-helix bundle cytokine primarily produced by CD4⁺ T cells, playing a central role in the regulation of adaptive immunity.

Interleukin-17A (IL-17A), commonly referred to as IL-17, is a key cytokine in the human immune defense system.