Technical Articles

In tumor immunology and infectious immunology research, the dynamic monitoring of antigen-specific T cells is a core aspect for elucidating immune response mechanisms, evaluating vaccine efficacy, and developing immunotherapy strategies.

The pH-sensitive IgG labeling reagent (Deep Red) is a chemical tool for biological labeling, whose core characteristic lies in the significant alteration of fluorescence signal intensity with changes in environmental pH. This reagent is predominantly utilized for real-time, quantitative tracking of the internalization process of antibodies in live cells.

One of the main strategies for tumor cells to evade T cell recognition is to downregulate MHC molecule expression. When MHC molecules are deficient, tumor cells no longer present mutant antigens, causing T cells to lose their tracking and attacking targets, thus allowing them to proliferate "invisibly". This mechanism is particularly common in solid tumors, posing a huge challenge to immunotherapy