Technical Articles

This article focuses on the molecular characteristics and immunoregulatory functions of KLRG1, systematically elaborating its molecular mechanism as a member of the C-type lectin-like receptor family that delivers inhibitory signals through the ITIM motif, analyzing the expression characteristics of KLRG1 in terminally differentiated T cells and NK cells and its differentiated positioning relative to classical immune checkpoints, and exploring the dual therapeutic potential of KLRG1 in the two major fields of autoimmune diseases and tumor immunity.