Technical Articles

KRAS[G12D]/CRBN PROTAC Kit

Challenges in Targeting KRAS G12D Mutation and Novel PROTAC Technology Strategies

2026-01-23

The KRAS gene is one of the most frequently mutated proto-oncogenes in human cancers. Among the RAS gene family (KRAS, NRAS, HRAS), KRAS mutations account for approximately 85%, and its encoded protein serves as a critical molecular switch.

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Cancer
KRAS[G12D]/CRBN PROTAC Kit
Targeted therapy
Pancreatic cancer

Research Progress on the Biological Characteristics and Targeted Degradation Strategies of KRAS[G12D] Mutant

2026-01-09

The RAS gene family is the most commonly mutated gene family in human malignancies, with mutations present in approximately 30% of human tumors.

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Cancer
KRAS[G12D]/CRBN PROTAC Kit
Malignant tumor
Signal transduction

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