Technical Articles

LERK-3（Leukocyte-derived epidermal growth factor-like receptor kinase-3 ligand） It is a member of the epidermal growth factor like family and an important ligand of the neurotrophic factor receptor tyrosine kinase (Trk) family.

LERK-3 (Ephrin-A3/EFNA3), a glycosylphosphatidylinositol (GPI)-anchored membrane-associated protein belonging to the Ephrin ligand family, demonstrates distinctive structural characteristics critical for its biological functions. Recombinant LERK-3 production predominantly utilizes HEK293 expression systems, incorporating a C-terminal His-tag for affinity purification. Detailed structural analysis reveals four essential domains:

LERK-3 protein, also known as Ephrin-A3, is a member of the Eph family of receptor tyrosine kinases. The Eph family is the largest subfamily of receptor tyrosine kinases and plays crucial roles in mediating developmental events, particularly in the nervous system and erythropoiesis. LERK-3 protein, as a ligand for Eph receptors, is involved in cell-cell signaling, adhesion, and migration.